PUBLICATION
Advances in understanding the mechanism of zebrafish heart regeneration
- Authors
- Kikuchi, K.
- ID
- ZDB-PUB-140816-1
- Date
- 2014
- Source
- Stem cell research 13(3PB): 542-555 (Review)
- Registered Authors
- Kikuchi, Kazu
- Keywords
- none
- MeSH Terms
-
- Animals
- Heart/physiology*
- Humans
- Models, Animal
- Regeneration*
- Zebrafish/physiology*
- PubMed
- 25127427 Full text @ Stem Cell Res
Citation
Kikuchi, K. (2014) Advances in understanding the mechanism of zebrafish heart regeneration. Stem cell research. 13(3PB):542-555.
Abstract
The adult mammalian heart was once believed to be a post-mitotic organ without any capacity for regeneration, but recent findings have challenged this dogma. A modified view assigns the mammalian heart a measurable capacity for regeneration throughout its lifetime, with the implication that endogenous regenerative capacity can be therapeutically stimulated in the injury setting. Although extremely limited in adult mammals, the natural capacity for organ regeneration is a conserved trait in certain vertebrates. Urodele amphibians and teleosts are well-known examples of such animals that can efficiently regenerate various organs including the heart as adults. By understanding how these animals regenerate a damaged heart, one might obtain valuable insights into how regeneration can be augmented in injured human hearts. Among the regenerative vertebrate models, the teleost zebrafish, Danio rerio, is arguably the best characterized with respect to cardiac regenerative responses. Knowledge is still limited, but a decade of research in this model has led to results that may help to understand how cardiac regeneration is naturally stimulated and maintained. This review surveys recent advances in the field and discusses current understanding of the endogenous mechanisms of cardiac regeneration in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping