ZFIN ID: ZDB-PUB-140812-4
Short Stories on Zebrafish Long Noncoding RNAs
Haque, S., Kaushik, K., Leonard, V.E., Kapoor, S., Sivadas, A., Joshi, A., Scaria, V., Sivasubbu, S.
Date: 2014
Source: Zebrafish   11(6): 499-508 (Review)
Registered Authors: Joshi, Adita, Sivasubbu, Sridhar
Keywords: none
MeSH Terms:
  • Age Factors
  • Animals
  • Gene Expression Regulation, Developmental/genetics*
  • Genetic Variation*
  • High-Throughput Nucleotide Sequencing
  • Phenotype*
  • RNA, Long Noncoding/genetics*
  • Transcriptome
  • Zebrafish/genetics*
PubMed: 25110965 Full text @ Zebrafish
The recent re-annotation of the transcriptome of human and other model organisms, using next-generation sequencing approaches, has unravelled a hitherto unknown repertoire of transcripts that do not have a potential to code for proteins. These transcripts have been largely classified into an amorphous class popularly known as long noncoding RNAs (lncRNA). This discovery of lncRNAs in human and other model systems have added a new layer to the understanding of gene regulation at the transcriptional and post-transcriptional levels. In recent years, three independent studies have discovered a number of lncRNAs expressed in different stages of zebrafish development and adult tissues using a high-throughput RNA sequencing approach, significantly adding to the repertoire of genes known in zebrafish. A subset of these transcripts also shows distinct and specific spatiotemporal patterns of gene expression, pointing to a tight regulatory control and potential functional roles in development, organogenesis, and/ or homeostasis. This review provides an overview of the lncRNAs in zebrafish and discusses how their discovery could provide new insights into understanding biology, explaining mutant phenotypes, and helping in potentially modeling disease processes.