PUBLICATION

The roles and regulation of multicellular rosette structures during morphogenesis

Authors
Harding, M.J., McGraw, H.F., Nechiporuk, A.
ID
ZDB-PUB-140626-7
Date
2014
Source
Development (Cambridge, England)   141: 2549-2558 (Review)
Registered Authors
Harding, Molly, McGraw, Hillary, Nechiporuk, Alex
Keywords
Drosophila epithelium, Morphogenesis, Myosin II, Rosette, Zebrafish lateral line
MeSH Terms
  • Animals
  • Body Patterning/physiology*
  • Cell Adhesion/physiology*
  • Cytoskeleton/physiology
  • Drosophila melanogaster
  • Epithelial Cells/physiology*
  • Humans
  • Kidney Tubules/embryology
  • Lateral Line System/embryology
  • Models, Biological*
  • Morphogenesis/physiology*
  • Neural Tube/embryology
  • Pancreas/embryology
  • Photoreceptor Cells, Invertebrate/physiology
  • Xenopus laevis
  • Zebrafish
PubMed
24961796 Full text @ Development
Abstract
Multicellular rosettes have recently been appreciated as important cellular intermediates that are observed during the formation of diverse organ systems. These rosettes are polarized, transient epithelial structures that sometimes recapitulate the form of the adult organ. Rosette formation has been studied in various developmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Drosophila epithelium and retina, as well as in the adult neural stem cell niche. These studies have revealed that the cytoskeletal rearrangements responsible for rosette formation appear to be conserved. By contrast, the extracellular cues that trigger these rearrangements in vivo are less well understood and are more diverse. Here, we review recent studies of the genetic regulation and cellular transitions involved in rosette formation. We discuss and compare specific models for rosette formation and highlight outstanding questions in the field.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping