Emerging from the PAC: Studying zebrafish lymphatic development
- Mulligan, T.S., Weinstein, B.M.
- Microvascular Research 96: 23-30 (Review)
- Registered Authors
- Mulligan, Tim, Weinstein, Brant M.
- Lymphatic, development, endothelial cells, lymphangiogenesis, zebrafish
- MeSH Terms
- Animals, Genetically Modified
- Cell Movement
- Endothelial Cells/cytology
- Endothelium, Lymphatic/embryology*
- Endothelium, Lymphatic/physiology
- Fluorescent Dyes
- Genes, Reporter
- Lymphatic Vessels/embryology*
- Lymphatic Vessels/physiology
- Time Factors
- 24928500 Full text @ Microvasc. Res.
Mulligan, T.S., Weinstein, B.M. (2014) Emerging from the PAC: Studying zebrafish lymphatic development. Microvascular Research. 96:23-30.
Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenics lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Although many questions remain, studying lymphatic development in the zebrafish has resulted in the identification and characterization of novel and established mediators of lymphatic development and lymphangiogenesis. Here, we review the main stages involved in the development of the lymphatic vasculature in the zebrafish from its origins in the embryonic veins to the formation of the primary lymphatic vessels and highlight some of the key molecules necessary for these stages.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes