PUBLICATION

Emerging from the PAC: Studying zebrafish lymphatic development

Authors
Mulligan, T.S., Weinstein, B.M.
ID
ZDB-PUB-140615-5
Date
2014
Source
Microvascular Research   96: 23-30 (Review)
Registered Authors
Mulligan, Tim, Weinstein, Brant M.
Keywords
Lymphatic, development, endothelial cells, lymphangiogenesis, zebrafish
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cell Movement
  • Endothelial Cells/cytology
  • Endothelium, Lymphatic/embryology*
  • Endothelium, Lymphatic/physiology
  • Fluorescent Dyes
  • Genes, Reporter
  • Lymphangiogenesis
  • Lymphatic Vessels/embryology*
  • Lymphatic Vessels/physiology
  • Time Factors
  • Transgenes
  • Zebrafish
PubMed
24928500 Full text @ Microvasc. Res.
Abstract
Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenics lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Although many questions remain, studying lymphatic development in the zebrafish has resulted in the identification and characterization of novel and established mediators of lymphatic development and lymphangiogenesis. Here, we review the main stages involved in the development of the lymphatic vasculature in the zebrafish from its origins in the embryonic veins to the formation of the primary lymphatic vessels and highlight some of the key molecules necessary for these stages.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes