PUBLICATION
Interplay between intercellular signaling and cell movement in development
- Authors
- Uriu, K., Morelli, L.G., Oates, A.C.
- ID
- ZDB-PUB-140603-10
- Date
- 2014
- Source
- Seminars in cell & developmental biology 35C: 66-72 (Review)
- Registered Authors
- Oates, Andrew
- Keywords
- Cell movement, Convergent extension, Intercellular signaling, Neural crest migration, Segmentation clock, Vertebrate axis elongation
- MeSH Terms
-
- Animals
- Body Patterning/physiology
- Cell Differentiation/physiology
- Cell Movement/physiology*
- Embryonic Development/physiology*
- Extracellular Space/physiology
- Models, Biological*
- Neural Crest/cytology
- Neural Crest/embryology
- Neural Crest/physiology
- Signal Transduction/physiology*
- PubMed
- 24882723 Full text @ Sem. Cell Dev. Biol.
Citation
Uriu, K., Morelli, L.G., Oates, A.C. (2014) Interplay between intercellular signaling and cell movement in development. Seminars in cell & developmental biology. 35C:66-72.
Abstract
Cell movement and local intercellular signaling are crucial components of morphogenesis during animal development. Intercellular signaling regulates the collective movement of a cell population via direct cell-cell contact. Cell movement, conversely, can influence local intercellular signaling by rearranging neighboring cells. Here, we first discuss theoretical models that address how intercellular signaling regulates collective cell movement during development. Examples include neural crest cell migration, convergent extension, and cell movement during vertebrate axis elongation. Second, we review theoretical studies on how cell movement may affect intercellular signaling, using the segmentation clock in zebrafish as an example. We propose that interplay between cell movement and intercellular signaling must be considered when studying morphogenesis in embryonic development.
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Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
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