PUBLICATION
Inflammation and wound repair
- Authors
- LeBert, D.C., Huttenlocher, A.
- ID
- ZDB-PUB-140524-4
- Date
- 2014
- Source
- Seminars in immunology 26(4): 315-320 (Review)
- Registered Authors
- Huttenlocher, Anna
- Keywords
- Chronic wounds, Inflammation, Regeneration, Wound repair
- MeSH Terms
-
- Animals
- Inflammation/immunology
- Leukocytes/immunology
- Models, Animal
- Regeneration
- Signal Transduction
- Wound Healing
- Zebrafish/immunology*
- Zebrafish/physiology*
- PubMed
- 24853879 Full text @ Semin. Immunol.
Citation
LeBert, D.C., Huttenlocher, A. (2014) Inflammation and wound repair. Seminars in immunology. 26(4):315-320.
Abstract
Wound repair requires the integration of complex cellular networks to restore tissue homeostasis. Defects in wound repair are associated with human disease including pyoderma gangrenosum, a heterogeneous disorder that is characterized by unhealed wounds and chronic inflammation of unclear etiology. Despite its clinical importance, there remain significant gaps in understanding how different types of cells communicate to integrate inflammation and wound repair. Recent progress in wound and regenerative biology has been gained by studying genetically tractable model organisms, like zebrafish, that retain the ability to regenerate. The optical transparency and ease of genetic manipulation make zebrafish an ideal model system to dissect multi-cellular and tissue level interactions during wound repair. The focus of this review is on recent advances in understanding how inflammation and wound repair are orchestrated and integrated to achieve wound resolution and tissue regeneration using zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping