|ZFIN ID: ZDB-PUB-140513-243|
Perspectives on antigen presenting cells in zebrafish
Lewis, K.L., Del Cid, N., Traver, D.
|Source:||Developmental and comparative immunology 46(1): 63-73 (Journal)|
|Registered Authors:||Traver, David|
|Keywords:||Antigen-presenting cells, B lymphocytes, Dendritic cells, Macrophages, Zebrafish|
|PubMed:||24685511 Full text @ Dev. Comp. Immunol.|
Lewis, K.L., Del Cid, N., Traver, D. (2014) Perspectives on antigen presenting cells in zebrafish. Developmental and comparative immunology. 46(1):63-73.
ABSTRACTAntigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.
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