PUBLICATION
Perspectives on antigen presenting cells in zebrafish
- Authors
- Lewis, K.L., Del Cid, N., Traver, D.
- ID
- ZDB-PUB-140513-243
- Date
- 2014
- Source
- Developmental and comparative immunology 46(1): 63-73 (Journal)
- Registered Authors
- Traver, David
- Keywords
- Antigen-presenting cells, B lymphocytes, Dendritic cells, Macrophages, Zebrafish
- MeSH Terms
-
- Animals
- Antigen-Presenting Cells/immunology*
- B-Lymphocytes/immunology
- Dendritic Cells/immunology
- Histocompatibility Antigens/immunology
- Macrophages/immunology
- Vertebrates/immunology
- Zebrafish/immunology*
- PubMed
- 24685511 Full text @ Dev. Comp. Immunol.
Citation
Lewis, K.L., Del Cid, N., Traver, D. (2014) Perspectives on antigen presenting cells in zebrafish. Developmental and comparative immunology. 46(1):63-73.
Abstract
Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping