ZFIN ID: ZDB-PUB-140513-243
Perspectives on antigen presenting cells in zebrafish
Lewis, K.L., Del Cid, N., Traver, D.
Date: 2014
Source: Developmental and comparative immunology   46(1): 63-73 (Journal)
Registered Authors: Traver, David
Keywords: Antigen-presenting cells, B lymphocytes, Dendritic cells, Macrophages, Zebrafish
MeSH Terms:
  • Animals
  • Antigen-Presenting Cells/immunology*
  • B-Lymphocytes/immunology
  • Dendritic Cells/immunology
  • Histocompatibility Antigens/immunology
  • Macrophages/immunology
  • Vertebrates/immunology
  • Zebrafish/immunology*
PubMed: 24685511 Full text @ Dev. Comp. Immunol.
Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.