PUBLICATION
Zebrafish models for translational neuroscience research: from tank to bedside
- Authors
- Stewart, A.M., Braubach, O., Spitsbergen, J., Gerlai, R., Kalueff, A.V.
- ID
- ZDB-PUB-140513-155
- Date
- 2014
- Source
- Trends in neurosciences 37: 264-278 (Review)
- Registered Authors
- Spitsbergen, Jan
- Keywords
- anxiety, biomarkers, brain disorders, cancer, epilepsy, zebrafish
- MeSH Terms
-
- Animals
- Brain Diseases/therapy
- Disease Models, Animal
- Humans
- Neurosciences*
- Translational Research, Biomedical/methods*
- Zebrafish
- PubMed
- 24726051 Full text @ Trends Neurosci.
Citation
Stewart, A.M., Braubach, O., Spitsbergen, J., Gerlai, R., Kalueff, A.V. (2014) Zebrafish models for translational neuroscience research: from tank to bedside. Trends in neurosciences. 37:264-278.
Abstract
The zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brain cancer, epilepsy, and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience. We further evaluate the contribution of zebrafish to neuroimaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping