PUBLICATION
Zebrafish as a model of cardiac disease
- Authors
- Wilkinson, R.N., Jopling, C., van Eeden, F.J.
- ID
- ZDB-PUB-140513-110
- Date
- 2014
- Source
- Progress in molecular biology and translational science 124: 65-91 (Chapter)
- Registered Authors
- Jopling, Chris, Wilkinson, Robert
- Keywords
- Arrhythmia, Cardiac disease, Cardiomyopathy, Congenital heart defects, Disease model, Heart development, Heart regeneration, Zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Electrophysiological Phenomena
- Heart/embryology
- Heart/physiology
- Heart Diseases/pathology*
- Regeneration/physiology
- Zebrafish/embryology
- Zebrafish/physiology*
- PubMed
- 24751427 Full text @ Prog. Mol. Biol. Transl. Sci.
Citation
Wilkinson, R.N., Jopling, C., van Eeden, F.J. (2014) Zebrafish as a model of cardiac disease. Progress in molecular biology and translational science. 124:65-91.
Abstract
The zebrafish has been rapidly adopted as a model for cardiac development and disease. The transparency of the embryo, its limited requirement for active oxygen delivery, and ease of use in genetic manipulations and chemical exposure have made it a powerful alternative to rodents. Novel technologies like TALEN/CRISPR-mediated genome engineering and advanced imaging methods will only accelerate its use. Here, we give an overview of heart development and function in the fish and highlight a number of areas where it is most actively contributing to the understanding of cardiac development and disease. We also review the current state of research on a feature that we only could wish to be conserved between fish and human; cardiac regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping