PUBLICATION
The zebrafish as a model of vascular development and disease
- Authors
- Wilkinson, R.N., van Eeden, F.J.
- ID
- ZDB-PUB-140513-109
- Date
- 2014
- Source
- Progress in molecular biology and translational science 124: 93-122 (Chapter)
- Registered Authors
- Wilkinson, Robert
- Keywords
- Angiogenesis, Blood vessel, Vascular disease, Vasculogenesis, Zebrafish
- MeSH Terms
-
- Animals
- Blood Vessels/embryology*
- Blood Vessels/pathology
- Disease Models, Animal
- Humans
- Lymphangiogenesis
- Muscle Development
- Vascular Diseases/pathology*
- Zebrafish/embryology*
- Zebrafish/physiology*
- PubMed
- 24751428 Full text @ Prog. Mol. Biol. Transl. Sci.
Citation
Wilkinson, R.N., van Eeden, F.J. (2014) The zebrafish as a model of vascular development and disease. Progress in molecular biology and translational science. 124:93-122.
Abstract
The zebrafish has recently emerged as an important animal model to study the formation of the vertebrate vascular network. The small size, optical translucency, and genetic tractability of the zebrafish embryo, in combination with an abundance of fluorescent transgenic lines which permit direct visualization of in vivo vessel formation, have greatly advanced our understanding of vascular biology. Widespread adoption of this powerful system has led to many important discoveries in relation to the mechanisms that underlie blood vessel formation. This review highlights the contribution of the zebrafish system to the current understanding of blood vessel formation and the use of zebrafish to model human vascular disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping