PUBLICATION
Developing better and more valid animal models of brain disorders
- Authors
- Stewart, A.M., and Kalueff, A.V.
- ID
- ZDB-PUB-140303-15
- Date
- 2015
- Source
- Behavioural brain research 276C: 28-31 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Mental Disorders*
- Validation Studies as Topic
- PubMed
- 24384129 Full text @ Behav. Brain Res.
Citation
Stewart, A.M., and Kalueff, A.V. (2015) Developing better and more valid animal models of brain disorders. Behavioural brain research. 276C:28-31.
Abstract
Valid sensitive animal models are crucial for understanding the pathobiology of complex human disorders, such as anxiety, autism, depression and schizophrenia, which all have the ‘spectrum’ nature. Discussing new important strategic directions of research in this field, here we focus i) on cross-species validation of animal models, ii) ensuring their population (external) validity, and iii) the need to target the interplay between multiple disordered domains. We note that optimal animal models of brain disorders should target evolutionary conserved ‘core’ traits/domains and specifically mimic the clinically relevant inter-relationships between these domains.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping