ZFIN ID: ZDB-PUB-131121-4
TBP2 is a general transcription factor specialized for female germ cells
Muller, F., and Tora, L.
Date: 2009
Source: Journal of biology   8(11): 97 (Review)
Registered Authors: Müller, Ferenc
Keywords: none
MeSH Terms:
  • Animals
  • Female
  • Germ Cells/metabolism
  • Germ Cells/physiology*
  • Humans
  • Nuclear Proteins/genetics
  • Nuclear Proteins/physiology*
  • Oocytes/metabolism
  • Oocytes/physiology*
  • TATA Box Binding Protein-Like Proteins/genetics
  • TATA Box Binding Protein-Like Proteins/physiology*
  • Transcription Factors/genetics
  • Transcription Factors/physiology*
PubMed: 19951399 Full text @ J. Biol.

The complexity of the core promoter transcription machinery has emerged as an additional level of transcription regulation that is used during vertebrate development. Recent studies, including one published in BMC Biology, provide mechanistic insights into how the TATA binding protein (TBP) and its vertebrate-specific paralog TBP2 (TRF3) switch function during the transition from the oocyte to the embryo.