Faucherre, A., Nargeot, J., Mangoni, M.E., and Jopling, C. (2013) piezo2b Regulates Vertebrate Light Touch Response. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(43):17089-17094.
The sense of touch allows an organism to detect and respond to physical environmental stimuli. Mechanosensitive proteins play
a crucial role in this process by converting the mechanical cue into a biological response. Recently, the Piezo family of
stretch-activated ion channels has been identified as genuine mechanosensitive proteins. We set out to determine whether any
of these genes are involved in touch response during zebrafish development. In situ hybridization indicates that piezo2b is specifically expressed in a subset of neurons (Rohon–Beard cells) responsible for detecting light touch. Using morpholino-mediated
knockdown, we specifically targeted piezo2b and determined that it is involved in mediating touch-evoked response.