ZFIN ID: ZDB-PUB-131120-1
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
Zon, L.I.,
Date: 2008
Source: Nature   453: 306-313 (Review)
Registered Authors: Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Epigenesis, Genetic
  • Hematopoietic Stem Cells/cytology*
  • Hematopoietic Stem Cells/metabolism
  • Homeodomain Proteins/genetics
  • Homeodomain Proteins/metabolism
  • Homeostasis/drug effects
  • Humans
  • Regeneration/drug effects
  • Regeneration/physiology*
  • Signal Transduction/drug effects
PubMed: 18480811 Full text @ Nature
When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.