PUBLICATION
Recent advances in heart regeneration
- Authors
- Xiong, J.W., and Chang N.N.
- ID
- ZDB-PUB-131029-22
- Date
- 2013
- Source
- Birth defects research. Part C, Embryo today : reviews 99(3): 160-169 (Review)
- Registered Authors
- Xiong, Jing-Wei
- Keywords
- cardiac progenitors, cardiac tissue engineering, heart regeneration, zebrafish, mouse
- MeSH Terms
-
- Animals
- Cell Proliferation
- Disease Models, Animal
- Humans
- Mice
- Myocardium/cytology*
- Myocardium/metabolism*
- Myocytes, Cardiac/transplantation
- Regeneration*
- Regenerative Medicine/methods*
- Stem Cell Transplantation
- Stem Cells
- Tissue Engineering/methods
- Zebrafish
- PubMed
- 24078494 Full text @ Birth Defects Res. C Embryo Today
Citation
Xiong, J.W., and Chang N.N. (2013) Recent advances in heart regeneration. Birth defects research. Part C, Embryo today : reviews. 99(3):160-169.
Abstract
Although cardiac stem cells (CSCs) and tissue engineering are very promising for cardiac regenerative medicine, studies with model organisms for heart regeneration will provide alternative therapeutic targets and opportunities. Here, we present a review on heart regeneration, with a particular focus on the most recent work in mouse and zebrafish. We attempt to summarize the recent progresses and bottlenecks of CSCs and tissue engineering for heart regeneration; and emphasize what we have learned from mouse and zebrafish regenerative models on discovering crucial genetic and epigenetic factors for stimulating heart regeneration; and speculate the potential application of these regenerative factors for heart failure. A brief perspective highlights several important and promising research directions in this exciting field.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping