PUBLICATION
Zebrafish-based small molecule screens for novel cardiovascular drugs
- Authors
- Novodvorsky, P., da Costa, M.M.J., and Chico, T.J.A.
- ID
- ZDB-PUB-131010-4
- Date
- 2013
- Source
- Drug Discovery Today: Technologies 10(1): e109-e114 (Review)
- Registered Authors
- Chico, Tim J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cardiovascular Agents*
- Drug Evaluation, Preclinical
- High-Throughput Screening Assays*
- Zebrafish*
- PubMed
- 24050238 Full text @ Drug Discov. Today Technol.
Citation
Novodvorsky, P., da Costa, M.M.J., and Chico, T.J.A. (2013) Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies. 10(1):e109-e114.
Abstract
The zebrafish is increasingly being adopted as an in vivo model of high throughput drug screening. In this brief review we outline the advantages and disadvantages of this approach and summarize recent screens that have attempted to identify novel small molecules with activity on the cardiovascular system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping