PUBLICATION
Swimming into prominence: the zebrafish as a valuable tool for studying human myopathies and muscular dystrophies
- Authors
- Gibbs, E.M., Horstick, E.J., and Dowling, J.J.
- ID
- ZDB-PUB-130710-99
- Date
- 2013
- Source
- The FEBS journal 280(17): 4187-97 (Review)
- Registered Authors
- Dowling, Jim
- Keywords
- zebrafish, muscular dystrophy, birefringence, drug discovery, myopathy
- MeSH Terms
-
- Animals
- Biomedical Research*
- Disease Models, Animal*
- Humans
- Muscular Diseases/genetics
- Muscular Diseases/pathology*
- Muscular Dystrophies/genetics
- Muscular Dystrophies/pathology*
- Zebrafish/genetics*
- PubMed
- 23809187 Full text @ FEBS J.
Citation
Gibbs, E.M., Horstick, E.J., and Dowling, J.J. (2013) Swimming into prominence: the zebrafish as a valuable tool for studying human myopathies and muscular dystrophies. The FEBS journal. 280(17):4187-97.
Abstract
A new and exciting phase of muscle disease research has recently been entered. The application of next generation sequencing technology has spurred an unprecedented era of gene discovery for both myopathies and muscular dystrophies. Gene-based therapies for Duchenne muscular dystrophy have entered clinical trial, and several pathway-based therapies are doing so as well for a handful of muscle diseases. While many factors have aided the extraordinary developments in gene discovery and therapy development, the zebrafish model system has emerged as a vital tool in these advancements.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping