PUBLICATION
Comparison of developmental toxicity of seven perfluoroalkyl acids to zebrafish embryos
- Authors
- Ulhaq, M., Carlsson, G., Orn, S., and Norrgren, L.
- ID
- ZDB-PUB-130710-9
- Date
- 2013
- Source
- Environmental Toxicology and Pharmacology 36(2): 423-426 (Journal)
- Registered Authors
- Norrgren, Leif
- Keywords
- perfluoroalkyl acids, zebrafish, embryo, toxicity
- MeSH Terms
-
- Animals
- Carboxylic Acids/chemistry
- Carboxylic Acids/toxicity*
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian/drug effects
- Fluorocarbons/chemistry
- Fluorocarbons/toxicity*
- Molecular Structure
- Structure-Activity Relationship
- Sulfonic Acids/chemistry
- Sulfonic Acids/toxicity*
- Zebrafish/embryology
- PubMed
- 23770452 Full text @ Environ. Toxicol. Pharmacol.
Citation
Ulhaq, M., Carlsson, G., Orn, S., and Norrgren, L. (2013) Comparison of developmental toxicity of seven perfluoroalkyl acids to zebrafish embryos. Environmental Toxicology and Pharmacology. 36(2):423-426.
Abstract
The toxicity of individual perfluoroalkyl acids (PFAAs) has been suggested to be determined by the carbon chain length as well as the functional group attached. We tested seven different PFAAs including both sulfonic and carboxylic PFAAs with different chain length to evaluate the developmental toxicity in zebrafish embryos. Generally, the acute toxicity of PFAAs is relatively low to zebrafish embryos. The EC50 values ranged from 1.5 to 2200 mg/L. We observed a relationship between higher toxicity with longer carbon chain. In addition, we also observed a higher toxicity for sulfonic PFAAs than for carboxylic PFAAs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping