Identification of Inter-Organ Vascular Network: Vessels Bridging between Organs

Omae, M., Takada, N., Yamamoto, S., Nakajima, H., and Sato, T.N.
PLoS One   8(6): e65720 (Journal)
Registered Authors
Nakajima, Hiroyuki, Omae, Madoka, Sato, Thomas N., Takada, Norio
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Cardiovascular System/embryology
  • Liver/blood supply*
  • Microscopy, Confocal
  • Neovascularization, Physiologic
  • Pancreas/blood supply*
  • Regional Blood Flow
  • Time-Lapse Imaging
  • Zebrafish
23799039 Full text @ PLoS One

Development and homeostasis of organs and whole body is critically dependent on the circulatory system. In particular, the circulatory system, the railways shuttling oxygen and nutrients among various organs, is indispensible for inter-organ humoral communication. Since the modern view of the anatomy and mechanics of the circulatory system was established in 17th century, it has been assumed that humoral factors are carried to and from organs via vascular branches of the central arteries and veins running along the body axis. Over the past few decades, major advances have been made in understanding molecular and cellular mechanisms underlying the vascularization of organs. However, very little is known about how each organ is linked by vasculature (i.e., inter-organ vascular networks). In fact, the exact anatomy of inter-organ vascular networks has remained obscure. Herein, we report the identification of four distinct vessels, V1LP, V2LP, V3LP and V4LP, that bridge between two organs, liver and pancreas in developing zebrafish. We found that these inter-organ vessels can be classified into two types: direct and indirect types. The direct type vessels are those that bridge between two organs via single distinct vessel, to which V1LP and V2LP vessels belong. The indirect type bridges between two organs via separate branches that emanate from a stem vessel, and V3LP and V4LP vessels belong to this type. Our finding of V1LP, V2LP, V3LP and V4LP vessels provides the proof of the existence of inter-organ vascular networks. These and other yet-to-be-discovered inter-organ vascular networks may facilitate the direct exchange of humoral factors that are necessary for the coordinated growth, differentiation and homeostasis of the connected organs. It is also possible that the inter-organ vessels serve as tracks for their connected organs to follow during their growth to establish their relative positions and size differences.

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