PUBLICATION

Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection

Authors
Nuster, R., Schmitner, N., Wurzinger, G., Gratt, S., Salvenmoser, W., Meyer, D., and Paltauf, G.
ID
ZDB-PUB-130607-11
Date
2013
Source
Journal of biophotonics   6(6-7): 549-559 (Journal)
Registered Authors
Meyer, Dirk, Schmitner, Nicole
Keywords
photoacoustic imaging, optoacoustic imaging, ultrasound imaging, section imaging, acoustic mirror, optical detection
MeSH Terms
  • Animals
  • Female
  • Melanocytes/cytology
  • Multimodal Imaging/methods*
  • Photoacoustic Techniques
  • Ultrasonics*
  • Zebrafish
PubMed
23650129 Full text @ J. Biophotonics
Abstract

A setup is proposed that provides perfectly co-registered photoacoustic (PA) and ultrasound (US) section images. Photoacoustic and ultrasound backscatter signals are generated by laser pulses coming from the same laser system, the latter by absorption of some of the laser energy on an optically absorbing target near the imaged object. By measuring both signals with the same optical detector, which is focused into the selected section by use of a cylindrical acoustic mirror, the information for both images is acquired simultaneously. Co-registered PA and US images are obtained after applying the inverse Radon transform to the data, which are gathered while rotating the object relative to the detector. Phantom experiments demonstrate a resolution of 1.1 mm between the sections of both imaging modalities and a in-plane resolution of about 60 μm and 120 μm for the US and PA modes, respectively. The complementary contrast mechanisms of the two modalities are shown by images of a zebrafish.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes