PUBLICATION
Imaging zebrafish neural circuitry from whole brain to synapse
- Authors
- Leung, L.C., Wang, G.X., and Mourrain, P.
- ID
- ZDB-PUB-130604-25
- Date
- 2013
- Source
- Frontiers in neural circuits 7: 76 (Journal)
- Registered Authors
- Mourrain, Philippe
- Keywords
- zebrafish, clinical neuroscience, psychiatry, calcium imaging, synapse imaging, array tomography, whole brain imaging
- MeSH Terms
-
- Animals
- Brain/cytology
- Brain/physiology*
- Calcium Signaling/physiology*
- Humans
- Molecular Imaging/methods
- Nerve Net/cytology
- Nerve Net/physiology*
- Synapses/physiology*
- Zebrafish
- PubMed
- 23630470 Full text @ Front. Neural Circuits
Citation
Leung, L.C., Wang, G.X., and Mourrain, P. (2013) Imaging zebrafish neural circuitry from whole brain to synapse. Frontiers in neural circuits. 7:76.
Abstract
Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap by which a zebrafish researcher can navigate the course from collecting neural activities across the brain associated with a behavior, to unraveling molecular identities and testing the functional relevance of active neurons. In doing so, important insights will be gained as to how neural networks generate behaviors and assimilate changes in synaptic connectivity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping