Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos
- Authors
- Wang, K., Ma, J., He, M., Gao, G., Xu, H., Sang, J., Wang, Y., Zhao, B., and Cui, D.
- ID
- ZDB-PUB-130429-13
- Date
- 2013
- Source
- Theranostics 3(4): 258-266 (Journal)
- Registered Authors
- Zhao, Baoquan
- Keywords
- upconversion nanoparticles (UCNPs), biocompatibility, toxicity, zebrafish embryo
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian/drug effects*
- Heart Rate/drug effects
- Intestines/drug effects
- Larva/drug effects
- Locomotion/drug effects
- Luminescence
- Nanoparticles/chemistry
- Nanoparticles/toxicity*
- Toxicity Tests
- Zebrafish
- PubMed
- 23606912 Full text @ Theranostics
This study reports the effects of upconversion nanoparticles (UCNPs) LaF3:Yb,Er on zebrafish, with the aim of investigating UCNPs toxicity. LaF3:Yb,Er were prepared by an oleic acid/ionic liquid two-phase system, and characterized by transmission electron microscope and X-ray powder diffraction. 140 zebrafish embryos were divided into six test groups and one control group, and respectively were injected into 5, 25, 50, 100, 200, 400 μg/mL LaF3:Yb,Er@SiO2 solution, and respectively were raised for 5 days. Each experiment was repeated ten times. Results showed that water-soluble LaF3:Yb,Er were successfully prepared, and did not exhibit obvious toxicity to zebrafish embryos under 100 μg/mL, but exhibited chronic toxicities 200 μg/mL in vivo, resulting in malformations and delayed hatching rate and embryonic and larval development. The excretion channels of LaF3:Yb,Er in adult zebrafish were mainly found in the intestine after being injected evenly for 24 h. In conclusion, the exploration of LaF3:Yb,Er for in vivo applications in animals and humans must consider UCNPs biocompatibility.