Assessment of nanosilver toxicity during zebrafish (Danio rerio) development
- Authors
- Massarsky, A., Dupuis, L., Taylor, J., Eisa-Beygi, S., Strek, L., Trudeau, V.L., and Moon, T.W.
- ID
- ZDB-PUB-130412-14
- Date
- 2013
- Source
- Chemosphere 92(1): 59-66 (Journal)
- Registered Authors
- Eisa-Beygi, Shahram, Trudeau, V.L.
- Keywords
- zebrafish, nanomaterials, nanosilver, toxicity, oxidative stress, cysteine
- MeSH Terms
-
- Animals
- Cysteine/chemistry
- Embryonic Development/drug effects*
- Glutathione/metabolism
- Heart Rate/drug effects
- Metal Nanoparticles/chemistry
- Metal Nanoparticles/toxicity*
- Oxidative Stress/drug effects
- Reactive Oxygen Species/metabolism
- Silver/chemistry
- Silver Nitrate/chemistry
- Silver Nitrate/toxicity
- Water Pollutants, Chemical/chemistry
- Water Pollutants, Chemical/toxicity*
- Zebrafish/growth & development*
- PubMed
- 23548591 Full text @ Chemosphere
Nanomaterials (NMs) including silver nanoparticles (AgNPs) are incorporated into an increasing number of consumer and medical products. However, the potential toxicity of AgNPs to aquatic organisms is largely unknown. This study characterizes the effects of AgNPs on zebrafish (Danio rerio) development. The effects of silver ions (Ag+) and AgNPs were examined at equivalent Ag concentrations, which ranged from 0.03 to 1.55 μg mL1 total Ag. The Ag+ was more toxic than AgNPs but both lead to death and delayed hatching in surviving embryos. Both silver types depleted glutathione levels but generally did not affect antioxidant enzymes activities. In addition to silver some of the embryos were also exposed to cysteine, which generally reduced the toxicity of both silver types. This study demonstrates that AgNPs and Ag+ are capable of inducing toxicity in zebrafish embryos including the induction of oxidative stress.