ZFIN ID: ZDB-PUB-130410-1
A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging
Zhou, Y., Yao, Y.W., Qi, Q., Fang, Y., Li, J.Y., and Yao, C.
Date: 2013
Source: Chemical communications (Cambridge, England)   49(53): 5924-6 (Journal)
Registered Authors: Zhou, Yi
Keywords: none
MeSH Terms:
  • Alkynes/chemistry*
  • Animals
  • Azides/analysis*
  • Azides/chemistry
  • Click Chemistry
  • Diagnostic Imaging
  • Fluorescent Dyes/chemistry*
  • HeLa Cells
  • Humans
  • Zebrafish
PubMed: 23525157 Full text @ Chem. Commun. (Camb.)

Here we present a new approach to aqueous hydrazoic acid detection through the synthesis and evaluation of an alkyne-based fluorescent probe, which could be applied in the monitoring of hydrazoic acid in both living Hela cells and larval zebrafish. This probe can also serve as an early warning automaton which would alert when both azide and protons exist over the threshold value.