Ricci, A.J., Bai, J.P., Song, L., Lv, C., Zenisek, D., and Santos-Sacchi, J. (2013) Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(7):3131-3134.
Zebrafish are popular models for biological discovery. For investigators of the auditory and vestibular periphery, manipulations
of hair cell and synaptic mechanisms have relied on inferences from extracellular recordings of physiological activity. We
now provide data showing that hair cells and supporting cells of the lateral line can be directly patch-clamped, providing
the first recordings of ionic channel activity, synaptic vesicle release, and gap junctional coupling in the neuromasts of
living fish. Such capabilities will allow more detailed understanding of mechano-sensation of the zebrafish.
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