ZFIN ID: ZDB-PUB-130307-3
Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish
Ricci, A.J., Bai, J.P., Song, L., Lv, C., Zenisek, D., and Santos-Sacchi, J.
Date: 2013
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience   33(7): 3131-3134 (Journal)
Registered Authors: Lv, Caixia, Zenisek, David
Keywords: none
MeSH Terms:
  • Animals
  • Female
  • Functional Laterality/physiology
  • Gap Junctions/physiology
  • Hair Cells, Auditory/physiology*
  • Larva
  • Lateral Line System/innervation*
  • Lateral Line System/physiology*
  • Male
  • Neurons/physiology*
  • Patch-Clamp Techniques*
  • Potassium Channels/physiology
  • Synaptic Vesicles/physiology
  • Zebrafish
PubMed: 23407967 Full text @ J. Neurosci.
ABSTRACT

Zebrafish are popular models for biological discovery. For investigators of the auditory and vestibular periphery, manipulations of hair cell and synaptic mechanisms have relied on inferences from extracellular recordings of physiological activity. We now provide data showing that hair cells and supporting cells of the lateral line can be directly patch-clamped, providing the first recordings of ionic channel activity, synaptic vesicle release, and gap junctional coupling in the neuromasts of living fish. Such capabilities will allow more detailed understanding of mechano-sensation of the zebrafish.

ADDITIONAL INFORMATION No data available