ZFIN ID: ZDB-PUB-130221-17
Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
Chen, Y.H., Wang, W.H., Wang, Y.H., Lin, Z.Y., Wen, C.C., and Chern, C.Y.
Date: 2013
Source: Molecules   18(2): 2052-2060 (Journal)
Registered Authors: Chen, Yau-Hung
Keywords: none
MeSH Terms:
  • Animal Fins/surgery
  • Animals
  • Anti-Inflammatory Agents/chemical synthesis
  • Anti-Inflammatory Agents/chemistry
  • Anti-Inflammatory Agents/pharmacology*
  • Chalcone/analogs & derivatives*
  • Chalcone/chemical synthesis
  • Chalcone/chemistry
  • Chalcone/pharmacology*
  • Larva/drug effects
  • Larva/enzymology
  • Models, Animal
  • Neutrophil Infiltration/drug effects
  • Peroxidase/metabolism
  • Wound Healing/drug effects
  • Zebrafish/metabolism*
PubMed: 23385341 Full text @ Molecules
ABSTRACT

The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.

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