ZFIN ID: ZDB-PUB-121220-45
Optogenetics in a transparent animal: circuit function in the larval zebrafish
Portugues, R., Severi, K.E., Wyart, C., and Ahrens, M.B.
Date: 2013
Source: Current opinion in neurobiology   23(1): 119-126 (Review)
Registered Authors: Severi, Kristen, Wyart, Claire
Keywords: none
MeSH Terms:
  • Animals
  • Behavior, Animal/physiology*
  • Brain/physiology*
  • Larva
  • Optogenetics/methods*
  • Zebrafish/physiology*
PubMed: 23246238 Full text @ Curr. Opin. Neurobiol.

Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.