PUBLICATION
[Use of zebrafish models for the research of traditional Chinese medicine]
- Authors
- Wang, Y.H., Li, S., Yang, B.R., Zhang, L.Q., Zhou, X., Hoi, P.M., and Lee, S.M.
- ID
- ZDB-PUB-121205-14
- Date
- 2012
- Source
- Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 10(11): 1189-1197 (Unknown)
- Registered Authors
- Wang, Youhua
- Keywords
- none
- MeSH Terms
-
- Animals
- Drug Design*
- Drug Evaluation, Preclinical
- Medicine, Chinese Traditional*
- Models, Biological*
- Zebrafish*
- PubMed
- 23158936 Full text @ Zhong Xi Yi Jie He Xue Bao
Citation
Wang, Y.H., Li, S., Yang, B.R., Zhang, L.Q., Zhou, X., Hoi, P.M., and Lee, S.M. (2012) [Use of zebrafish models for the research of traditional Chinese medicine]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 10(11):1189-1197.
Abstract
Traditional Chinese medicine (TCM) exhibits a broad range of effects on biological activity that is probably due to interactions of complex chemical constituents with multiple targets in the body. Understanding the active chemical constituents in TCM is very important in providing rationales for the clinical usage of TCM. The zebrafish (Danio rerio) has recently become a popular model in the field of drug screening, specifically emerging as an important vertebrate model for in vivo high-content drug screening of multiple efficacy parameters and whole-organism toxicity. The authors also discussed the advantages of the zebrafish model for evaluating drug metabolism. Zebrafish usage in TCM screening should be a viable approach that helps identify active chemical markers, biological pathways and mechanistic actions of TCM.
Errata / Notes
Article in Chinese.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping