ZFIN ID: ZDB-PUB-121127-7
Planar cell polarity signaling in craniofacial development
Topczewski, J., Dale, R.M., and Sisson, B.E.
Date: 2011
Source: Organogenesis   7(4): 255-259 (Review)
Registered Authors: Dale, Rodney M., Sisson, Barbara E., Topczewski, Jacek
Keywords: none
MeSH Terms:
  • Animals
  • Cell Polarity*
  • Face/embryology*
  • Neural Crest/cytology
  • Signal Transduction*
  • Skull/cytology*
  • Skull/embryology*
  • Wnt Proteins/metabolism
PubMed: 22134372 Full text @ Organogenesis

Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.