ZFIN ID: ZDB-PUB-121116-6
Inflammation drives wound hyperpigmentation by recruiting pigment cells to sites of tissue damage
Lévesque, M., Feng, Y., Jones, R., and Martin, P.
Date: 2013
Source: Disease models & mechanisms   6(2): 508-515 (Journal)
Registered Authors: Feng, Yi, Jones, Rebecca Amy, Lévesque, Mathieu, Martin, Paul
Keywords: none
MeSH Terms:
  • Aging/pathology
  • Animals
  • Cell Differentiation/immunology
  • Cell Movement/immunology
  • Humans
  • Hyperpigmentation/complications*
  • Hyperpigmentation/immunology
  • Hyperpigmentation/pathology*
  • Immunity, Innate/immunology
  • Inflammation/complications
  • Inflammation/pathology*
  • Larva/metabolism
  • Melanocytes/metabolism
  • Melanocytes/pathology*
  • Skin/immunology
  • Skin/pathology*
  • Skin Pigmentation*/immunology
  • Wound Healing/immunology
  • Zebrafish/metabolism*
PubMed: 23104990 Full text @ Dis. Model. Mech.

In humans, skin is the largest organ serving as a barrier between our body and the outside world. Skin protects our internal organs from external pathogens and other contaminants, and melanocytes within the skin protect the body from ultraviolet light damage. These same pigment cells also determine our skin colour and complexion. Skin wounding triggers a repair response that includes a robust recruitment of inflammatory cells which function to kill invading microbes and clear away cell and matrix debris; once at the wound site these innate immune cells release a barrage of cytokines that direct other cells' activities during the repair process. Tissue damage and repair also frequently leads to alterations in skin pigmentation, in particular leading to wound hyperpigmentation. In this study we describe a model of wound hyperpigmentation in the translucent zebrafish larva where we can live image the recruitment of melanocytes and their precursors, melanoblasts, to the wound site. We show that these pigment cells are drawn in after the initial recruitment of innate immune cells and that the inflammatory response is essential for wound hyperpigmentation. This new model will allow us to uncover the molecular link between immune and pigment cells during tissue repair and screen for potential therapeutics to dampen wound hyperpigmentation.