PUBLICATION

ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics

Authors
Howe, D.G., Bradford, Y.M., Conlin, T., Eagle, A.E., Fashena, D., Frazer, K., Knight, J., Mani, P., Martin, R., Moxon, S.A., Paddock, H., Pich, C., Ramachandran, S., Ruef, B.J., Ruzicka, L., Schaper, K., Shao, X., Singer, A., Sprunger, B., Van Slyke, C.E., and Westerfield, M.
ID
ZDB-PUB-121030-8
Date
2013
Source
Nucleic acids research   41(D1): D854-860 (Review)
Registered Authors
Bradford, Yvonne, Conlin, Tom, Eagle, Anne, Fashena, David, Frazer, K., Howe, Doug, Knight, Jonathan, Mani, Prita, Martin, Ryan, Moxon, Sierra (fka Taylor), Paddock, Holly, Pich, Christian, Ramachandran, Sridhar, Ruef, Barbara, Ruzicka, Leyla, Schaper, Kevin, Shao, Xiang, Singer, Amy, Sprunger, Brock, Van Slyke, Ceri E., Westerfield, Monte
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Databases, Genetic*
  • Genomics
  • Internet
  • Models, Animal
  • Mutation
  • Phenotype
  • Zebrafish/genetics*
PubMed
23074187 Full text @ Nucleic Acids Res.
Abstract

ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is the central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate and integrate comprehensive data involving zebrafish genes, mutants, transgenics, phenotypes, genotypes, gene expressions, morpholinos, antibodies, anatomical structures and publications. Integrated views of these data, as well as data gathered through collaborations and data exchanges, are provided through a wide selection of web-based search forms. Among the vertebrate model organisms, zebrafish are uniquely well suited for rapid and targeted generation of mutant lines. The recent rapid production of mutants and transgenic zebrafish is making management of data associated with these resources particularly important to the research community. Here, we describe recent enhancements to ZFIN aimed at improving our support for mutant and transgenic lines, including (i) enhanced mutant/transgenic search functionality; (ii) more expressive phenotype curation methods; (iii) new downloads files and archival data access; (iv) incorporation of new data loads from laboratories undertaking large-scale generation of mutant or transgenic lines and (v) new GBrowse tracks for transgenic insertions, genes with antibodies and morpholinos.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes