ZFIN ID: ZDB-PUB-121019-12
Cardiac regenerative capacity and mechanisms
Kikuchi, K., and Poss, K.D.
Date: 2012
Source: Annual Review of Cell and Developmental Biology   28: 719-741 (Review)
Registered Authors: Kikuchi, Kazu, Poss, Kenneth D.
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Heart/physiopathology*
  • Humans
  • Myocardial Infarction/pathology
  • Myocardial Infarction/physiopathology
  • Myocytes, Cardiac/physiology
  • Regeneration*
  • Regenerative Medicine
  • Stem Cells/physiology
PubMed: 23057748 Full text @ Annu. Rev. Cell Dev. Biol.

The heart holds the monumental yet monotonous task of maintaining circulation. Although cardiac function is critical to other organs and to life itself, mammals are not equipped with significant natural capacity to replace heart muscle that has been lost by injury. This deficiency plays a role in leaving millions worldwide vulnerable to heart failure each year. By contrast, certain other vertebrate species such as zebrafish are strikingly good at heart regeneration. A cellular and molecular understanding of endogenous regenerative mechanisms and advances in methodology to transplant cells together project a future in which cardiac muscle regeneration can be therapeutically stimulated in injured human hearts. This review focuses on what has been discovered recently about cardiac regenerative capacity and how natural mechanisms of heart regeneration in model systems are stimulated and maintained.