PUBLICATION

Myelopoiesis during zebrafish early development

Authors
Xu, J., Du, L., and Wen, Z.
ID
ZDB-PUB-121010-22
Date
2012
Source
Journal of genetics and genomics = Yi chuan xue bao   39(9): 435-442 (Review)
Registered Authors
Wen, Zilong
Keywords
zebrafish, hematopoiesis, myelopoiesis
MeSH Terms
  • Animals
  • Cell Differentiation*
  • Cell Lineage
  • Embryo, Nonmammalian
  • Embryonic Development*
  • Gene Expression Regulation, Developmental
  • Granulocytes/cytology
  • Humans
  • Macrophages/cytology
  • Monocytes/cytology
  • Myelopoiesis*/genetics
  • Myelopoiesis*/physiology
  • Zebrafish/embryology*
PubMed
23021543 Full text @ J. Genet. Genomics
Abstract

Myelopoiesis is the process of producing all types of myeloid cells including monocytes/macrophages and granulocytes. Myeloid cells are known to manifest a wide spectrum of activities such as immune surveillance and tissue remodeling. Irregularities in myeloid cell development and their function are known to associate with the onset and the progression of a variety of human disorders such as leukemia. In the past decades, extensive studies have been carried out in various model organisms to elucidate the molecular mechanisms underlying myelopoiesis with the hope that these efforts will yield knowledge translatable into therapies for related diseases. Zebrafish has recently emerged as a prominent animal model for studying myelopoiesis, especially during early embryogenesis, largely owing to its unique properties such as transparent embryonic body and external development. This review introduces the methodologies used in zebrafish research and focuses on the recent research progresses of zebrafish myelopoiesis.

Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes