PUBLICATION
Cancer and inflammation: an aspirin a day keeps the cancer at bay
- Authors
- Mione, M., and Zon, L.I.
- ID
- ZDB-PUB-120718-25
- Date
- 2012
- Source
- Current biology : CB 22(13): R522-525 (Review)
- Registered Authors
- Mione, Marina, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Transformation, Neoplastic/metabolism*
- Dinoprostone/metabolism*
- Leukocytes/metabolism*
- Zebrafish/genetics*
- PubMed
- 22789999 Full text @ Curr. Biol.
Citation
Mione, M., and Zon, L.I. (2012) Cancer and inflammation: an aspirin a day keeps the cancer at bay. Current biology : CB. 22(13):R522-525.
Abstract
Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE2 promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE2 production and could be used with other anti-tumor agents in the treatment of cancer.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping