Yan, H., Teh, C., Sreejith, S., Zhu, L., Kwok, A., Fang, W., Ma, X., Nguyen, K.T., Korzh, V., and Zhao, Y. (2012) Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo. Angewandte Chemie (International ed. in English). 51(33):8373-8377.
A new class of photothermal-responsive rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon trans–cis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.