ZFIN ID: ZDB-PUB-120718-13
Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo
Yan, H., Teh, C., Sreejith, S., Zhu, L., Kwok, A., Fang, W., Ma, X., Nguyen, K.T., Korzh, V., and Zhao, Y.
Date: 2012
Source: Angewandte Chemie (International ed. in English)   51(33): 8373-8377 (Journal)
Registered Authors: Korzh, Vladimir, Teh, Cathleen
Keywords: drug delivery, mesoporous silica nanoparticles, nanoparticles, photothermal switches, zebrafish
MeSH Terms:
  • Animals
  • Curcumin/chemistry
  • Drug Delivery Systems*
  • Larva
  • Nanoparticles/administration & dosage*
  • Nanoparticles/chemistry
  • Photochemical Processes
  • Porosity
  • Rotaxanes/chemistry
  • Silicon Dioxide/administration & dosage*
  • Silicon Dioxide/chemistry
  • Surface Properties
  • Temperature*
  • Zebrafish
PubMed: 22777795 Full text @ Angew. Chem. Int. Ed. Engl.

A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon transcis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.