PUBLICATION
Hooked! Modeling human disease in zebrafish
- Authors
- Santoriello, C., and Zon, L.I.
- ID
- ZDB-PUB-120706-12
- Date
- 2012
- Source
- J. Clin. Invest. 122(7): 2337-2343 (Review)
- Registered Authors
- Santoriello, Cristina, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Central Nervous System Diseases/drug therapy
- Central Nervous System Diseases/genetics
- Disease Models, Animal*
- Drug Screening Assays, Antitumor*
- Eye Diseases/genetics
- Female
- Genetic Engineering
- Heart Diseases/genetics
- Heart Diseases/pathology
- Hematologic Diseases/genetics
- Humans
- Kidney Diseases/genetics
- Kidney Diseases/pathology
- Male
- Muscular Dystrophy, Duchenne/drug therapy
- Muscular Dystrophy, Duchenne/genetics
- Neoplasms/drug therapy
- Neoplasms/genetics
- Zebrafish/anatomy & histology
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 22751109 Full text @ J. Clin. Invest.
Citation
Santoriello, C., and Zon, L.I. (2012) Hooked! Modeling human disease in zebrafish. J. Clin. Invest.. 122(7):2337-2343.
Abstract
Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping