PUBLICATION

Hooked! Modeling human disease in zebrafish

Authors
Santoriello, C., and Zon, L.I.
ID
ZDB-PUB-120706-12
Date
2012
Source
J. Clin. Invest.   122(7): 2337-2343 (Review)
Registered Authors
Santoriello, Cristina, Zon, Leonard I.
Keywords
none
MeSH Terms
  • Kidney Diseases/genetics
  • Kidney Diseases/pathology
  • Genetic Engineering
  • Muscular Dystrophy, Duchenne/drug therapy
  • Muscular Dystrophy, Duchenne/genetics
  • Animals
  • Central Nervous System Diseases/drug therapy
  • Central Nervous System Diseases/genetics
  • Zebrafish/anatomy & histology
  • Zebrafish/genetics*
  • Zebrafish/physiology
  • Heart Diseases/genetics
  • Heart Diseases/pathology
  • Eye Diseases/genetics
  • Disease Models, Animal*
  • Hematologic Diseases/genetics
  • Humans
  • Male
  • Neoplasms/drug therapy
  • Neoplasms/genetics
  • Drug Screening Assays, Antitumor*
  • Female
PubMed
22751109 Full text @ J. Clin. Invest.
Abstract

Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping