Zhang, J., Liss, M., Wolburg, H., Blasig, I.E., and Abdelilah-Seyfried, S. (2012) Involvement of claudins in zebrafish brain ventricle morphogenesis. Annals of the New York Academy of Sciences. 1257(1):193-198.
Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow– and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial–ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood–brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.
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