Involvement of claudins in zebrafish brain ventricle morphogenesis
- Authors
- Zhang, J., Liss, M., Wolburg, H., Blasig, I.E., and Abdelilah-Seyfried, S.
- ID
- ZDB-PUB-120608-2
- Date
- 2012
- Source
- Annals of the New York Academy of Sciences 1257(1): 193-198 (Review)
- Registered Authors
- Abdelilah-Seyfried, Salim
- Keywords
- brain ventricle morphogenesis, tight junction, claudin-5a, claudin-3
- MeSH Terms
-
- Animals
- Cerebral Ventricles/embryology*
- Cerebral Ventricles/metabolism
- Claudins/genetics
- Claudins/metabolism*
- Morphogenesis
- Organogenesis
- Phylogeny
- Tight Junctions/metabolism*
- Zebrafish/embryology*
- Zebrafish/metabolism
- Zebrafish Proteins/metabolism*
- PubMed
- 22671606 Full text @ Ann N Y Acad Sci
Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow– and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial–ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood–brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.