Muscle diseases in the zebrafish
- Authors
- Lin, Y.Y.
- ID
- ZDB-PUB-120601-1
- Date
- 2012
- Source
- Neuromuscular disorders : NMD 22(8): 673-684 (Review)
- Registered Authors
- Lin, Yung-Yao
- Keywords
- zebrafish, muscle, disease model, muscular distrophy, myopathy, sarcomere, danio rerio
- MeSH Terms
-
- Animals
- Biomedical Research/trends
- Disease Models, Animal*
- Drug Discovery/trends
- Genomics
- Muscular Diseases/drug therapy
- Muscular Diseases/genetics*
- Muscular Diseases/physiopathology
- Sarcomeres/physiology
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 22647769 Full text @ Neuromuscul. Disord.
Animal models in biomedical research are important for understanding the pathological mechanisms of human diseases at a molecular and cellular level. Several aspects of mammalian animals, however, may limit their use in modelling neuromuscular disorders. Many attributes of zebrafish (Danio rerio) are complementary to mammalian experimental systems, establishing the zebrafish as a powerful model organism in disease biology. This review focuses on a number of key studies using the zebrafish to model hereditary muscle diseases with additional emphasis on recent advances in zebrafish functional genomics and drug discovery. Increasing research in zebrafish disease models, combined with knowledge from mammalian models, will bring novel insights into the disease pathogenesis of neuromuscular disorders, as well as facilitate the development of effective therapeutic strategies.