PUBLICATION
Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche
- Authors
- Patton, E.E.
- ID
- ZDB-PUB-120529-16
- Date
- 2012
- Source
- The Journal of pathology 227(4): 381-384 (Review)
- Registered Authors
- Patton, E. Elizabeth
- Keywords
- micrometastasis, zebrafish, VEGFR, xenograft, neutrophil
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Humans
- Neoplasm Metastasis/physiopathology*
- Neutrophils/physiology*
- Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors*
- Xenograft Model Antitumor Assays*
- Zebrafish/embryology*
- PubMed
- 22611003 Full text @ J. Pathol.
Citation
Patton, E.E. (2012) Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche. The Journal of pathology. 227(4):381-384.
Abstract
Non-cancerous immune cells can significantly contribute to tumour progression and metastases. Neutrophils associated with tumours can both promote and inhibit tumour progression, but less is known about how non-associated immune cells contribute to cancer biology. In a recent issue of the Journal of Pathology, He and colleagues use non-invasive, high-resolution imaging of the whole living animal to provide a compelling glimpse at how physiological migration of neutrophils can prepare a metastatic niche and how their activities can be altered by the unintended consequences of targeted therapeutics.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping