Toxicity assessment of zebrafish following exposure to CdTe QDs
- Authors
- Zhang, W., Lin, K., Miao, Y., Dong, Q., Huang, C., Wang, H., Guo, M., and Cui, X.
- ID
- ZDB-PUB-120306-9
- Date
- 2012
- Source
- Journal of hazardous materials 213-214: 413-420 (Journal)
- Registered Authors
- Zhang, Wei
- Keywords
- TGA-CdTe QDs, zebrafish, developmental toxicity, behavioral toxicity
- MeSH Terms
-
- Abnormalities, Drug-Induced/pathology
- Animals
- Blood Vessels/drug effects
- Blood Vessels/growth & development
- Blood Vessels/physiology
- Cadmium Compounds/toxicity*
- Embryo, Nonmammalian
- Female
- Growth/drug effects
- Heart Rate/drug effects
- Larva
- Male
- Photoperiod
- Quantum Dots*
- Reproduction
- Swimming/physiology
- Tellurium/toxicity*
- Zebrafish/physiology*
- PubMed
- 22381373 Full text @ J. Hazard. Mater.
CdTe quantum dots (QDs) are nanocrystals of unique composition and properties that have found many new commercial applications; therefore, their potential toxicity to aquatic organisms has become a hot research topic. The lab study was performed to determine the developmental and behavioral toxicities to zebrafish under continuous exposure to low concentrations of CdTe QDs (1–400 nM) coated with thioglycolic acid (TGA). The results show: (1) the 120 h LC50 of 185.9 nM, (2) the lower hatch rate and body length, more malformations, and less heart beat and swimming speed of the exposed zebrafish, (3) the brief burst and a higher basal swimming rate of the exposed zebrafish larvae during a rapid transition from light-to-dark, and (4) the vascular hyperplasia, vascular bifurcation, vascular crossing and turbulence of the exposed FLI-1 transgenic zebrafish larvae.