ZFIN ID: ZDB-PUB-120306-25
Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo
Zhou, Y., Li, J.Y., Chu, K.H., Liu, K., Yao, C., and Li, J.Y.
Date: 2012
Source: Chemical communications (Cambridge, England)   48(39): 4677-4679 (Journal)
Registered Authors: Zhou, Yi
Keywords: none
MeSH Terms:
  • Animals
  • Brain Chemistry
  • Ether/chemistry*
  • Fluoresceins/chemistry*
  • Fluorescent Dyes/chemistry*
  • Hypochlorous Acid/analysis*
  • Hypochlorous Acid/chemistry
  • Intestines/chemistry
  • Mice
  • NIH 3T3 Cells
  • Oxidation-Reduction
  • Solubility
  • Water/chemistry
  • Zebrafish/embryology
PubMed: 22389025 Full text @ Chem. Commun. (Camb.)

We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.