ZFIN ID: ZDB-PUB-120202-10
Flavone is efficient to protect zebrafish fins from UV-induced damage
Tsai, I.T., Yang, Z.S., Lin, Z.Y., Wen, C.C., Cheng, C.C., and Chen, Y.H.
Date: 2012
Source: Drug and chemical toxicology   35(3): 341-346 (Journal)
Registered Authors: Chen, Yau-Hung
Keywords: Chalcone, fin, flavone, UV, zebrafish
MeSH Terms:
  • Animal Fins/drug effects*
  • Animal Fins/radiation effects*
  • Animals
  • Apoptosis/radiation effects
  • Chalcone/chemistry
  • Chalcone/pharmacology
  • Flavanones/chemistry
  • Flavanones/pharmacology
  • Flavones/chemistry
  • Flavones/pharmacology*
  • In Situ Nick-End Labeling
  • Kaplan-Meier Estimate
  • Molecular Structure
  • Proportional Hazards Models
  • Radiation Injuries, Experimental/prevention & control*
  • Reactive Oxygen Species/metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ultraviolet Rays*
  • Zebrafish/embryology*
PubMed: 22289409 Full text @ Drug Chem. Toxicol.
We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.