PUBLICATION
Flavone is efficient to protect zebrafish fins from UV-induced damage
- Authors
- Tsai, I.T., Yang, Z.S., Lin, Z.Y., Wen, C.C., Cheng, C.C., and Chen, Y.H.
- ID
- ZDB-PUB-120202-10
- Date
- 2012
- Source
- Drug and chemical toxicology 35(3): 341-346 (Journal)
- Registered Authors
- Chen, Yau-Hung
- Keywords
- Chalcone, fin, flavone, UV, zebrafish
- MeSH Terms
-
- Animal Fins/drug effects*
- Animal Fins/radiation effects*
- Animals
- Apoptosis/radiation effects
- Chalcone/chemistry
- Chalcone/pharmacology
- Flavanones/chemistry
- Flavanones/pharmacology
- Flavones/chemistry
- Flavones/pharmacology*
- In Situ Nick-End Labeling
- Kaplan-Meier Estimate
- Molecular Structure
- Proportional Hazards Models
- Radiation Injuries, Experimental/prevention & control*
- Reactive Oxygen Species/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Ultraviolet Rays*
- Zebrafish/embryology*
- PubMed
- 22289409 Full text @ Drug Chem. Toxicol.
Citation
Tsai, I.T., Yang, Z.S., Lin, Z.Y., Wen, C.C., Cheng, C.C., and Chen, Y.H. (2012) Flavone is efficient to protect zebrafish fins from UV-induced damage. Drug and chemical toxicology. 35(3):341-346.
Abstract
We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping