|ZFIN ID: ZDB-PUB-120202-10|
Flavone is efficient to protect zebrafish fins from UV-induced damage
Tsai, I.T., Yang, Z.S., Lin, Z.Y., Wen, C.C., Cheng, C.C., and Chen, Y.H.
|Source:||Drug and chemical toxicology 35(3): 341-346 (Journal)|
|Registered Authors:||Chen, Yau-Hung|
|Keywords:||Chalcone, fin, flavone, UV, zebrafish|
|PubMed:||22289409 Full text @ Drug Chem. Toxicol.|
Tsai, I.T., Yang, Z.S., Lin, Z.Y., Wen, C.C., Cheng, C.C., and Chen, Y.H. (2012) Flavone is efficient to protect zebrafish fins from UV-induced damage. Drug and chemical toxicology. 35(3):341-346.
ABSTRACTWe used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
- Genes / Markers (3)