Retention and maternal transfer of environmentally relevant PBDD/Fs, PCDD/Fs and PCBs in zebrafish (Danio rerio) after dietary exposure
- Authors
- Arnoldsson, K., Haldén, A.N., Norrgren, L., and Haglund, P.
- ID
- ZDB-PUB-120127-10
- Date
- 2012
- Source
- Environmental toxicology and chemistry 31(4): 804-812 (Journal)
- Registered Authors
- Norrgren, Leif
- Keywords
- polybrominated dibenzo-p-dioxins, dietary uptake, metabolism, maternal transfer, zebrafish
- MeSH Terms
-
- Animals
- Benzofurans/pharmacokinetics*
- Diet
- Dioxins/pharmacokinetics*
- Environmental Exposure
- Environmental Monitoring
- Female
- Oceans and Seas
- Ovum/chemistry
- Polychlorinated Biphenyls/pharmacokinetics*
- Water Pollutants, Chemical/pharmacokinetics*
- Zebrafish/metabolism*
- PubMed
- 22278820 Full text @ Environ. Toxicol. Chem.
High levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), mono- and non-ortho polychlorinated biphenyls (PCBs), and polybrominated dibenzo-p-dioxins (PBDDs) are found in fish from coastal areas in the Baltic Sea, which may cause ecotoxicological effects. To increase our understanding of the persistency of the emerging pollutants polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), fish feed was spiked with 21 PBDD/Fs, 17 PCDD/Fs, and 30 PCBs and fed to zebrafish. Concentrations in fish and eggs were examined during a six- or twelve-week uptake period, and a six-week elimination period. Steady-state was reached for 2, 3, 7, and/or 8-substituted tri- and tetra-BDD/Fs, with 2,3,7,8-tetra-BDD (2,3,7,8-TeBDD) being the most strongly retained. Steady-state was not reached for tetra- to hexa-CDDs. Non-2,3,7,8-congeners showed little of or no retention. Most PCBs had high retention and did not reach steady-state. Half-lives decreased in the order: PCBs > PCDD/Fs > PBDD/Fs. Concentrations of 2,3,7,8-penta- to octa-CDD/Fs decreased with their degree of chlorination suggesting that the rate-limiting factor for uptake is low bioavailability. Maternal transfer was observed for all retained compounds, with most transfer factors < 1, indicating that transfer rates are affected by the poor water solubility of the compounds. The limited retention of the major PBDD congeners found in Baltic Sea fish suggests that they are exposed to high or very high concentrations via either food or water.