ZFIN ID: ZDB-PUB-120106-6
TOR-autophagy signaling in adult zebrafish models of cardiomyopathy
Ding, Y., Sun, X., and Xu, X.
Date: 2012
Source: Autophagy   8(1): 142-143 (Journal)
Registered Authors: Ding, Yonghe, Sun, Xiaojing, Xu, Xiaolei
Keywords: none
MeSH Terms:
  • Aging/pathology*
  • Animals
  • Autophagy*
  • Cardiomyopathies/enzymology*
  • Cardiomyopathies/pathology*
  • Cardiotonic Agents/metabolism
  • Disease Models, Animal
  • Doxorubicin
  • Signal Transduction*
  • TOR Serine-Threonine Kinases/metabolism*
  • Zebrafish/metabolism*
PubMed: 22186229 Full text @ Autophagy

The target of rapamycin (TOR) kinase is part of an evolutionarily conserved signaling pathway that coordinates cell growth, survival, and autophagy. Previously, pharmacological studies using rapamycin have suggested a cardioprotective effect of TOR signaling inhibition on cardiomyopathy. We found that rapamycin exerts a conserved cardioprotective effect in two adult zebrafish models of cardiomyopathy of different etiology, and provided the first genetic evidence to support a long-term cardioprotective effect of TOR signaling inhibition. Moreover, we detected dynamic TOR-autophagy activities along different stages of cardiomyopathy. This needs to be considered when developing TOR-autophagy-based therapeutics for cardiomyopathy.