PUBLICATION
Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo
- Authors
- Choi, V.W., Wong, M.Y., Cheng, S.H., and Yu, K.N.
- ID
- ZDB-PUB-111130-4
- Date
- 2012
- Source
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 70(7): 1075-1079 (Journal)
- Registered Authors
- Cheng, Shuk Han
- Keywords
- alpha particles, Bystander effect, zebrafish embryos, CO, CORM-3
- MeSH Terms
-
- Animals
- Apoptosis/drug effects
- Apoptosis/radiation effects
- Bystander Effect/drug effects*
- Carbon Monoxide/pharmacology*
- Embryo, Nonmammalian/drug effects*
- Embryo, Nonmammalian/radiation effects
- Zebrafish/embryology*
- PubMed
- 22119559 Full text @ Appl. Radiat. Isot.
Citation
Choi, V.W., Wong, M.Y., Cheng, S.H., and Yu, K.N. (2012) Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 70(7):1075-1079.
Abstract
In the present work, the influence of a low concentration of exogenous carbon monoxide (CO) liberated from tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the radiation induced bystander effect (RIBE) in vivo between embryos of the zebrafish was studied. RIBE was assessed through the number of apoptotic signals revealed on embryos at 25 h post fertilization (hpf). A significant attenuation of apoptosis on the bystander embryos induced by RIBE in a CO concentration dependent manner was observed.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping