PUBLICATION

Microarray Screening for Genes Involved in Oligodendrocyte Differentiation in the Zebrafish CNS

Authors
Chung, A.Y., Kim, S., Kim, H., Bae, Y.K., and Park, H.C.
ID
ZDB-PUB-111129-27
Date
2011
Source
Experimental Neurobiology   20(2): 85-91 (Journal)
Registered Authors
Bae, Young Ki, Park, Hae-Chul
Keywords
oligodendrocyte, differentiation, myelination, microarray, zebrafish
MeSH Terms
none
PubMed
22110365 Full text @ Exp. Neurobiol.
Abstract
Within the vertebrate nervous system, myelination is required for the normal function of neurons by facilitating the rapid conduction of action potentials along axons. Oligodendrocytes are glial cells which myelinate axons in the central nervous system. Disruption of myelination and remyelination failure can cause human diseases such as multiple sclerosis. Despite the importance of myelination, the molecular basis of oligodendrocyte differentiation and myelination are still poorly understood. To understand the molecular mechanisms which regulate oligodendrocyte differentiation and myelination, novel genes were identified using a microarray analysis. The analysis used oligodendrocyte lineage cells isolated from transgenic zebrafish expressing fluorescent proteins in the oligodendrocyte lineage cells. Seven genes not previously known to be involved in oligodendrocyte differentiation were identified, and their expression during oligodendrocyte development was validated.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes