ZFIN ID: ZDB-PUB-111117-24
Lzts2 Regulates Embryonic Cell Movements and Dorsoventral Patterning through Interaction with and Export of Nuclear β-Catenin in Zebrafish
Li, Y., Li, Q., Long, Y., and Cui, Z.
Date: 2011
Source: The Journal of biological chemistry   286(52): 45116-30 (Journal)
Registered Authors: Cui, Zongbin, Li, Qing, Long, Yong
Keywords: beta-catenin, bone morphogenetic protein (BMP), STAT3, Wnt signaling, zebrafish, convergence and extension, dorsoventral patterning, Lzts2
MeSH Terms:
  • Active Transport, Cell Nucleus/physiology
  • Animals
  • Body Patterning/physiology*
  • Cell Movement/physiology
  • Cell Nucleus/genetics
  • Cell Nucleus/metabolism*
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism*
  • Gastrula/cytology
  • Gastrula/metabolism*
  • Organogenesis/physiology
  • STAT3 Transcription Factor/genetics
  • STAT3 Transcription Factor/metabolism
  • Signal Transduction/physiology
  • Tumor Suppressor Proteins/genetics
  • Tumor Suppressor Proteins/metabolism*
  • Wnt Proteins/genetics
  • Wnt Proteins/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • beta Catenin/genetics
  • beta Catenin/metabolism*
PubMed: 22057270 Full text @ J. Biol. Chem.

Background: The activities of Leucine zipper tumor suppressor 2 (Lzts2) in vertebrate embryogenesis remain unclear.

Results: Lzts2 regulates gastrula C&E movements, dorsoventral patterning, and midline convergence and specification of organ precursors in zebrafish.

Conclusion: Lzts2 functions through interaction with and the export of nuclear β-catenins.

Significance: This work has uncovered the developmental roles of Lzts2 and regulatory mechanisms in zebrafish.