PUBLICATION
Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis
- Authors
- Goessling, W., and North, T.E.
- ID
- ZDB-PUB-111012-9
- Date
- 2011
- Source
- Methods in cell biology 105: 117-136 (Chapter)
- Registered Authors
- Goessling, Wolfram, North, Trista
- Keywords
- cell culture, hematopoietic, mesoderm, primitive, transgenic, transplantation
- MeSH Terms
-
- Animals
- Biomarkers/analysis
- Body Patterning/physiology
- Cell Culture Techniques*
- Cell Differentiation
- Developmental Biology/methods*
- Embryo, Nonmammalian/cytology*
- Embryo, Nonmammalian/physiology
- Flow Cytometry/methods*
- Genes, Reporter
- Hemangioblasts/cytology
- Hematopoiesis/physiology*
- Hematopoietic Stem Cells/cytology*
- Hematopoietic Stem Cells/physiology
- Hemodynamics
- Mesoderm/cytology
- Microscopy, Confocal/methods*
- Mutation
- Signal Transduction/physiology
- Zebrafish/embryology
- Zebrafish/physiology*
- Zebrafish Proteins/analysis
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 21951528 Full text @ Meth. Cell. Biol.
Citation
Goessling, W., and North, T.E. (2011) Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis. Methods in cell biology. 105:117-136.
Abstract
Hematopoietic stem cells (HSC) form the basis of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. The genetic programs regulating HSC development are highly conserved between vertebrate species. The zebrafish has proven to be an excellent model for discovering and characterizing the signaling networks and physical forces regulating vertebrate hematopoietic development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping