ZFIN ID: ZDB-PUB-111012-25
Chemical screening in zebrafish for novel biological and therapeutic discovery
Tan, J.L., and Zon, L.I.
Date: 2011
Source: Methods in cell biology   105: 491-516 (Chapter)
Registered Authors: Zon, Leonard I.
Keywords: chemical screening, hit detection, pharmacodynamic, pharmacokinetic, phenotype, modulation
MeSH Terms:
  • Animals
  • Automation, Laboratory
  • Behavior, Animal/drug effects
  • Behavior, Animal/physiology
  • Databases, Factual
  • Drug Discovery/methods*
  • Drug Evaluation, Preclinical/methods*
  • Embryo, Nonmammalian/drug effects
  • Embryo, Nonmammalian/physiology*
  • High-Throughput Screening Assays*
  • Humans
  • Immunohistochemistry
  • Molecular Targeted Therapy/methods*
  • Phenotype
  • Research Design
  • Small Molecule Libraries/pharmacology*
  • Zebrafish/embryology
  • Zebrafish/physiology*
PubMed: 21951544 Full text @ Meth. Cell. Biol.
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost-effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.