|ZFIN ID: ZDB-PUB-111012-25|
Chemical screening in zebrafish for novel biological and therapeutic discovery
Tan, J.L., and Zon, L.I.
|Source:||Methods in cell biology 105: 491-516 (Chapter)|
|Registered Authors:||Zon, Leonard I.|
|Keywords:||chemical screening, hit detection, pharmacodynamic, pharmacokinetic, phenotype, modulation|
|PubMed:||21951544 Full text @ Meth. Cell. Biol.|
Tan, J.L., and Zon, L.I. (2011) Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods in cell biology. 105:491-516.
ABSTRACTZebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost-effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.
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