PUBLICATION
The amphioxus Hox cluster: deuterostome posterior flexibility and Hox14
- Authors
- Ferrier, D.E., Minguillón, C., Holland, P.W., and Garcia-Fernàndez, J.
- ID
- ZDB-PUB-110928-1
- Date
- 2000
- Source
- Evolution & development 2(5): 284-293 (Journal)
- Registered Authors
- Minguillón, Carolina
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Chordata, Nonvertebrate/genetics*
- DNA Primers
- Genes, Homeobox*
- Molecular Sequence Data
- Multigene Family*
- Phylogeny
- Sequence Homology, Amino Acid
- PubMed
- 11252557 Full text @ Evol. Dev.
Citation
Ferrier, D.E., Minguillón, C., Holland, P.W., and Garcia-Fernàndez, J. (2000) The amphioxus Hox cluster: deuterostome posterior flexibility and Hox14. Evolution & development. 2(5):284-293.
Abstract
The amphioxus (Branchiostoma floridae) Hox cluster is a model for the ancestral vertebrate cluster, prior to the hypothesized genome-wide duplications that may have facilitated the evolution of the vertebrate body plan. Here we describe the posterior (52) genes of the amphioxus cluster, and report the isolation of four new homeobox genes. Vertebrates possess 13 types of Hox gene (paralogy groups), but we show that amphioxus possesses more than 13 Hox genes. Amphioxus is now the first animal in which a Hox14 gene has been found. Our mapping and phylogenetic analysis of amphioxus “Posterior Class” Hox genes reveals that these genes are evolving at a faster rate in deuterostomes than in protostomes, a phenomenon we term Posterior Flexibility.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping